Search results for " mesenchymal cell"

P2 receptors influence differentiation in human mesenchymal and ectomesenchymal stem cells

2010

Characterization of Rabbit Mesenchymal Cell Attachment on Calcium Phosphate Surface

2014

In the current study, the effect of three different treated surfaces of hydroxyapatite and β-tricalcium phosphate on mesenchymal cell attachment has been investigated. Calcium phosphate powders have been synthesized, uniaxially pressed, polished and sintered. Mesenchymal cells have been seeded onto unpolished, polished and polished-thermally etched ceramic samples. The ceramic samples have been characterized by XRD, FTIR and SEM. Results have shown that the best cell attachment and morphology are on the unpolished surface indicating that relatively rough surface is better for cell application.

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions

2021

BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…